Coarse-grained,foldable, physical model of the polypeptide chain

Although nonflexible, scaled molecular models like Pauling–Corey’s and its descendants have made significant contributions in structural biology research and pedagogy, recent technical advances in 3D printing and electronics make it possible to go one step further in designing physical models of biomacromolecules: to make them conformationally dynamic. We report here the design, construction, and validation of a flexible, scaled, physical model of the polypeptide chain, which accurately reproduces the bond rotational degrees of freedom in the peptide backbone. The coarse-grained backbone model consists of repeating amide and α-carbon units, connected by mechanical bonds (corresponding to φ and ψ) that include realistic barriers to rotation that closely approximate those found at the molecular scale. Longer-range hydrogen-bonding interactions are also incorporated, allowing the chain to readily fold into stable secondary structures. The model is easily constructed with readily obtainable parts and promises to be a tremendous educational aid to the intuitive understanding of chain folding as the basis for macromolecular structure. Furthermore, this physical model can serve as the basis for linking tangible biomacromolecular models directly to the vast array of existing computational tools to provide an enhanced and interactive human–computer interface.     

补气祛风法治疗小儿咳嗽变异性哮喘38例

目的观察补气祛风法治疗小儿咳嗽变异性哮喘的临床疗效。方法38例咳嗽变异性哮喘患儿均以补气祛风法为治疗原则，口服中药汤剂，并随症加减，7d后统计疗效。结果临床治愈19例，有效16例，无效3例，总有效率为92．11％。结论采用补气祛风法治疗小儿咳嗽变异性哮喘，既可提高患儿抗病能力，又可减轻机体对过敏因素的应激反应，抗复发、防演变，疗效显著。     

医院关键科室原有空调设施节能改造探讨

针对医院一般科室与关键科室不同的空气质量控制要求难以节能运行的问题，介绍了采用双冷源新风处理机组，在不改变原系统设施绔陶，既可有效解决关键科室的温湿度控制，保证新风处理达到无菌、湿度优先控制要求的具体节能改造方法。     

络病学说探析

"久病入络"是络病的主要病机,"络脉阻滞"是络病最基本的病理改变.络脉为病均有不同程度的气郁、血阻或痰结等"络瘀"表现,"通络"是总治则,细之又有"祛邪通络"、"扶正通络"两大类及宣络、透络、清络、活络、柔络、通络、搜络诸法.     

咳嗽变异性哮喘的中医证候学研究

目的 探讨咳嗽变异性哮喘患者的中医证候特点及演变规律.方法 通过文献复习及相关研究资料的整合分析,筛选出咳嗽变异性哮喘临床常见到的62项症状及舌脉象,制定出统一的证候学科研观察表,对265例咳嗽变异性哮喘患者进行系统的临床观察与研究.结果 初步总结出咳嗽变异性哮喘的核心症状及周边症状的特征性表现,并提出了以风邪犯肺为核心证型,其余5个基本证型(寒邪侵肺、热邪蕴肺、肝火犯肺、肺阴亏耗、肺气亏虚)可相互并见的证候学演变规律.结论 风邪犯肺、肺失宣肃是致病的关键所在,疏风必须贯穿疾病治疗的始终.     

祛风益气养阴治疗小儿咳嗽变异性哮喘

目的 观察祛风益气养阴治疗小儿咳嗽变异性哮喘的临床疗效,探究小儿咳嗽变异性哮喘的中医病因病机实质.方法 将90例患儿随机分为3组各30例.治疗组口服祛风止咳汤剂加养阴益气合剂;对照1组口服祛风止咳汤剂;对照2组口服西药美普清加养阴益气合剂.服药2个月后观察疗效.结果 3组疗效有显著性差异(P＜0.05),治疗组疗效明显优于对照1组(P＜0.05)、2组(P＜0.01).结论 祛风益气养阴治疗小儿咳嗽变异性哮喘具有良好的临床疗效.     

面神经麻痹中医证治体会

面神经麻痹是由于面神经炎引起的周围性面瘫,是临床常见病,多发病。认为治疗上以养血祛风法用于正气不足证,以驱邪祛风法用于风邪入络证,并提出内外合治,针药并用。     

天麻钩藤饮治疗椎-基底动脉供血不足90例

目的：探讨天麻钩藤饮治疗椎-基底动脉供血不足的疗效。方法：将180例椎-基底动脉供血不足患者随机分成两组，对照组90例给予天麻素胶囊，氟桂利嗪胶囊口服，治疗组90例加服天麻钩藤饮，每日1剂，早晚2次，水煎服。两组均15d为1个疗程。结论：天麻钩藤饮治疗椎-基底动脉供血不足疗效满意。     

卒中治风四法与微观证治学研究

为促进卒中微观证治学的传承与创新，应用微观证治学方法，从“风中五脏”立论，按肝风证治提出降压熄风、祛痰降脂、活血化瘀和降血糖的“治风四法”和相应药物，为防治高血压伴有动脉粥样硬化心脑血管病的首选方药。